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鲁式神经末梢与毛囊受体

Raja Narayan 创建

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and then down to the next mechanoreceptor this is another corpuscle right here we're familiar with corpuscles by now and it's named after another scientist this is ruffini's corpuscle ruffini's corpuscle and you may have actually seen this by another term ruffini's ending is another phrase they use for this mechanoreceptor and the idea is that if we have some external stimulus again this guy poking us all over again generating this force that goes deep within our skin ruffini's corpuscle which looks like this guy right here will perceive it and it's very interesting because there are no discs or rings like we had with the other corpuscles instead what you can kind of clearly see right here and this is so beautiful there's an actual nerve fiber right here and I'll outline it so that thing right here that's kind of being cast this way that's the nerve fiber this is our half errant nerve fiber right here do you remember what type it is I think I heard you say a beta so you're absolutely right so this is our afferent nerve fiber and actually this guy sort of branches into the corpuscle so ruffini's corpuscle right here has a whole bunch of afferent nerve fiber branches in it but I didn't highlight the whole thing here what else do we have hanging out up here well the other thing that we've got sort of coding this is collagen collagen you might remember is a structural protein so I'll draw just all around there and I'll label it right here so there's collagen right here collagen like what you might remember from the dermis and so what will happen is that if we stretch the skin up here with this external stimulus and we stretch it hard and we generate this force that goes deep into our skin and kind of hits ruffini's ending right here it'll cause the collagen here to shift and be perturbed and as you might notice the collagen is very intimately connected to the nerve fiber branches here and as the collagen shifts it opens up ion channels on these nerve branches that allow sodium that's kind of hanging out in the extracellular matrix to sneak in it'll sneak in and then kind of go along this afferent nerve fiber to generate an action potential and move on to the central nervous and that's really interesting because as long as this stretch or the stimulus is being applied to our skin we're going to have the collagen being stretched and pushed out of the way to allow sodium or other ions to enter into our afferent nerve fiber and so you might have guessed this is going to be one of those receptors that respond to sustained touch sustained touch but the trick here is because this depends heavily on collagen you got to think what part of our skin has the most amount of collagen well we're gonna have to go pretty deep for that because the part of our skin that has collagen is the dermis so it'll be the dermis but the dermis has two layers and the part of the dermis that has the most collagen is the reticular dermis so that's how you can reason that out it's sustained touch that causes the collagen to move and allow sodium to keep on entering and so where do we have the most collagen the reticular dermis and that's pretty deep awesome now let's move on to the last Meccano receptor the last mechanoreceptor we're going to talk about is called a hair follicle receptor a hair follicle receptor and I'm hoping there are some neurons firing in your brain right now about this because we talked a little earlier about a non-hairy receptor and now we're talking specifically about hair so this should be a callback to the hairy mechanoreceptor that'll close that story that we talked about at the beginning and likewise I'm gonna draw this stimulus a little differently this this perturbation right here will be something like this and I'll draw the nail if this is going to be like a finger and it's kind of initiating a force in that direction and if this is over a part of skin that's relatively hairy and there was hair here the hair will be deflected so that is deflected hair very beautiful shaft of hair right here that goes deep into the skin right because you remember that hair protrudes from a follicle okay so there's the hair shaft that goes at the bottom here and I'll draw a little follicle that kind of nests it right here so it kind of goes like this right here and that goes in the back and that comes out in the front and the interesting thing about the hair follicle is that there is a nerve fiber that is actually wrapped around the part of the hair that sits in the follicle and sure enough this is an afferent nerve fiber and a beta nerve fiber and what you'll notice is that when the hair is deflected that allows for ions to leak into this after nerve kind of where the hair and the nerve are interfacing and what it leaks in it kind of enters and you know goes along the length of this nerve and goes down here and that generates an action potential which can then convey a signal to our central nervous system and so this all started from hair deflection hair deflection was the impetus for this signal to occur and so this is going to be used to perceive light touch because we're not even touching the skin right here we're actually just touching the hair so it's light touch on hairy skin it's a light touch on hairy skin because our hairs are being deflected as we perceive the stimulus and while the hair kind of runs many layers of skin remember that the follicle itself this guy sits anchored in the reticular dermis it sits in the reticular dermis and so that's the location we subscribe the hair follicle receptor to and lastly as long as we're kind of pushing along right here what will happen is that the sodium will leak in so long as there's an active space that's present but because the reticular dermis is a place of such thick dense connective tissue if we push the hair shaft and make an opening right here remember that there's a ton of collagen kind of sitting around that can come and fill the gap and just block it so sodium could not enter so what does that mean this implies then that we need constantly changing stimuli in order to have a signal be generated and so this is the third of three mechanoreceptors that requires constantly changing stimuli so that the hair shaft can constantly be opening up a gap for sodium to enter and it has to do so around so much collagen that'll plug the opening if we just have the hair held deflected that's the whole point of why you don't notice a hairband that you might be wearing over a long period of time because that's definitely deflecting your hair but over time it's as noticeable as a smooth cotton t-shirt it's there but you're not constantly detecting it and it's important to emphasize that this is a very essential distinction from the other type of light touch we mentioned earlier with Merkel's disk